Automated two-step manufacturing of [11C]glyburide radiopharmaceutical for PET imaging in humans
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منابع مشابه
Gallium‐68 DOTATATE Production with Automated PET Radiopharmaceutical Synthesis System: A Three Year Experience
Objective(s): Gallium‐68 (Ga‐68) is an ideal research and hospital‐based PET radioisotope. Currently, the main form of Ga‐68 radiopharmaceutical that is being synthesised in‐house is Ga‐68 conjugated with DOTA based derivatives. The development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. Here we report on our three...
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This paper reports the results of an on-going research project at Cranfield University in collaboration with a leading consultant company. A major objective of the research to develop a new generation process planning system using the latest tools and technologies, and to fully comply with the international standard for exchange of product data (STEP) Application Protocol 224 (AP224) for proces...
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Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of pro...
متن کاملgallium‐68 dotatate production with automated pet radiopharmaceutical synthesis system: a three year experience
objective(s): gallium‐68 (ga‐68) is an ideal research and hospital‐based pet radioisotope. currently, the main form of ga‐68 radiopharmaceutical that is being synthesised in‐house is ga‐68 conjugated with dota based derivatives. the development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. here we report on our three...
متن کاملPreclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging.
[61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu] ATSM) was prepared using in house-made diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) ligand and [61Cu]CuCl2 produced via the natZn(p, x)61Cu (180 muA proton irradiation, 22 MeV, 3.2 h) and purified by a ion chromatography method. [61Cu]ATSM radiochemical purity was >98 %, as shown by HPLC and RTLC methods. [61Cu]ATSM was administered into...
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ژورنال
عنوان ژورنال: Nuclear Medicine and Biology
سال: 2020
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2019.12.008